Research Publications

Research publications by Scientissimum members

Research Publications

Authors: Zhalmukhamedov E.

Abstract - In the last 10 years neurosurgical practice has seen exponential growth that has shattered all the imaginary borders of its predecessors. From tremendous advancements in neuroendovascular care to treat stroke patients that have sustained symptoms more than 24 hours ago, to minimally invasive robotic spine surgery that discharges patients’ homes on the same day. All these advancements have drastically improved patient outcomes in the developed world. Many neurosurgical procedures have become more simplified and more intuitive thanks to computer software and hardware that guided neurosurgeons’ decisions in treating patients operatively. However, while all these advancements have proven efficacy and efficiency in the operating room, these technologies are rarely applied or used in low-and-middle-income countries due to a lack of awareness or financial issues. There is the vast majority of newer technologies, that many low and middle-income country hospitals are simply not aware of due to limitations in general awareness or lack of educational materials backing up their efficacy. Read this research now…


Authors: Zhalmukhamedov E.

Authors: Zhalmukhamedov E.

Abstract - Neurosurgery as a medical discipline has always been on the cutting edge of technology and the latest advancements. It’s not a surprise why modern neurosurgeons actively utilize various social media platforms, in order to share the latest news or showcase interesting cases they face daily. From Twitter to LinkedIn neurosurgical professionals of the world share the knowledge and connect with each other in order to advance their skills to the next level. A thought-provoking content is constantly shared and spark many interesting read this research now…


Authors: Zhalmukhamedov E.

Authors: Zhalmukhamedov E.

Abstract - The burden of spinal diseases contributes to overall global disability, economic hardship, morbidity and even opioid misuse. There are many surgical contributions to the global initiative of improving spine health. However, there are not so many participating chiropractic doctors who are involved in this agenda. Not only can chiropractic care drastically improve outcomes for certain spine and neuromuscular diseases, but it can also save thousands of dollars to participating organizations worldwide. The global healthcare initiative around the world aims for one particular goal, and that goal is to keep nations of low and middle-income countries (LMICs) healthy. Within the sphere of chiropody, there are three main areas of global focus: the healthy ageing, opioid misuse and women and children’s health read this research now…


Authors: Zhalmukhamedov E., Magloire C., Maidyrov E., Soans A, Elijio L., Nossov N., Mahbub S.

Authors: Zhalmukhamedov E., Magloire C., Maidyrov E., Soans A, Elijio L., Nossov N., Mahbub S.

Abstract - When we talk about the most scenic Caribbean islands, St. Lucia is one of those islands that certainly come into our mind. It is a beautiful tourist destination and the place of post-volcanic paradise on earth. However, just like many remote Caribbean islands, St. Lucians (name for local population) used to have its own difficulties of obtaining on demand basic neurosurgical services in their homeland. This beautiful Caribbean island, socioeconomically falls in the same category as most low-and middle-income countries (LMICs) and unfortunately echoes the same unmet surgical and anesthesia needs as the rest of them read this research now…


Author: E. Zhalmukhamedov, T. Urakov

Author: E. Zhalmukhamedov, T. Urakov

Abstract - For many years the same model has been applied to neurosurgical education; and unfortunately with the shift of healthcare to political and socioeconomic areas, it forced many surgical residents and fellows to limit their OR exposure only to certain cases. With limited resources given to graduate medical education facilities, now a more optimal approach to surgical education has to be adopted. There is a need for modern hands on, yet safe approach to crucial neurosurgical procedures read this research now…


Author: Jun-Yih Chen, Li-Wen Chu, Kuang-I Cheng, Su-Ling Hsieh, Yung-Shun Juan, Bin-Nan Wu

Author: Jun-Yih Chen, Li-Wen Chu, Kuang-I Cheng, Su-Ling Hsieh, Yung-Shun Juan, Bin-Nan Wu

Abstract - Valproate (VPA) is a well-known drug for treating epilepsy and mania, but its action in neuropathic pain is unclear. We used a chronic constriction injury (CCI) model to explore whether VPA prevents neuropathic pain-mediated inflammation and neuronal death. Rats were treated with or without VPA. CCI + VPA rats were intraperitoneally injected with VPA (300 mg/kg/day) from postoperative day (POD) 1 to 14. We measured paw withdrawal latency (PWL) and paw withdrawal threshold (PWT) 1 day before surgery and 1, 3, 7, 14 days after CCI and harvested the sciatic nerves (SN), spinal cord (SC) and dorsal root ganglia (DRG) on POD 3, 7, and 14 read this research now…


Author: E. Zhalmukhamedov

Author: E. Zhalmukhamedov

Abstract - The purpose of this review article is to showcase the importance of neurosurgical care in third world countries, including the lack of support and awareness among developed countries on this issue. A summary of available data on neurosurgical mission trips has been collected from PubMed and Google Scholar on the following mesh keywords: Neurosurgery trips, mission neurosurgery, and neurosurgery in third world countries. We gathered our information that was closely related to neurosurgical education such as proficiency, equipment, ethics and outcomes read this research now…


Author: T. Urakov

Author: T. Urakov

Abstract - Fluoroscopy use in spine surgery is increasing owing to the increasing popularity of minimally invasive techniques. The effectiveness and safe distance for protective barriers might have been commonly misrepresented. The present study evaluated x-ray propagation and the efficacy of protective barriers in the setting of spine surgery read this research now…


Author: E. Zhalmukhamedov

Author: E. Zhalmukhamedov

Abstract - As the world has widely adapted the principle of searching for relevant information online, many practicing physicians, especially those who are involved in specialty - must pay a close attention to their brand and their reputation on the World Wide Web. There are numerous web pages available to the general public about particular physician and where he/she practices. Most of those pages are either managed by a third party company or created for promotional use. Some physicians are not even read this research now…


Authors: Jessica K Campos, Li-Mei Lin, Narlin B Beaty, Matthew T Bender, Bowen Jiang, David A Zarrin, Alexander L Coon

Authors: Jessica K Campos, Li-Mei Lin, Narlin B Beaty, Matthew T Bender, Bowen Jiang, David A Zarrin, Alexander L Coon

Abstract - An estimated 2%–3% of the population harbour an intracranial aneurysm. Concomitant atherosclerotic cervical carotid disease is not uncommon. The management of these two entities remains a challenge within the field. We report a single case of concomitant carotid stenosis and two ipsilateral unruptured intracranial aneurysms treated with a single-staged cervical carotid stenting and cerebral aneurysm embolisation with the Pipeline embolisation device read this research now…


Authors: C.Magloire, R.Alcendor PhD

Authors: C.Magloire, R.Alcendor PhD

Abstract - Sirtuins are a family of proteins involved in metabolic and chromatin regulation throughout evolution.  These proteins modify cellular metabolism in response to altered nutrition or stress (Vassilopoulos, 2011).  Sirtuins promote expressions of genes involved in increasing longevity by inhibiting metabolic activity, reducing apoptosis, decreasing the effects of free radicals, and activating DNA repair enzymes (Kumar, 2015).  Each sirtuin has specific biological functions and are found in different compartments of the cell read this research now…



Author: E.Zhalmukhamedov

Author: E.Zhalmukhamedov

Abstract - The main aim for writing this research case study is to evaluate and improve current underserved hospital/health facility managerial practices, as well as patient centered approach to the general care. This paper discussed personally tested details of the modern marketing methods, best managerial practices and new pipeline of patient services that were created, during the time in the medical facility as an executive marketing manager. This paper will be an excellent source for physicians, administrative staff as well as clinical managers interested in improving overall healthcare facility and driving higher return on investment (ROI) read this research now...


Authors: C.Magloire, L.Elijio, E.Zhalmukhamedov

Authors: C.Magloire, L.Elijio, E.Zhalmukhamedov

Abstract - The shortage of physicians in rural America has been an ongoing topic for decades. Most scientific literature has addressed the lack of primary care physicians in rural areas. However, there is a substantial amount of data which also shows a scarcity of specialty physicians in these regions. This shortage of specialized doctors has not been as represented in scientific read this research now...


Author: E.Zhalmukhamedov

Author: E.Zhalmukhamedov

Abstract - As US Department of Health (DOH) continues to evaluate the ranking of hospitals throughout the country, it’s becoming imperative for the hospitals to keep their brand image on a positive side, as well as keep improving their services of patient outcome. This paper focuses on the important aspects of modern methods of healthcare marketing, as well as emergency marketing, such as how to deal with read this research now...